To use embedded fonts with Adobe Text Layout Framework (TLF) you need to switch on the 'embedAsCFF' option and use Flex SDK 4.0 to compile the fonts. Please note that the 'embedAsCFF' attribute replaced the old 'cff' attribute in Flex SDK 4.0. After succesfully embedding the fonts make sure that you set the fontLookup property of the TextFLow to FontLookup.EMBEDDED_CFF.
// Embedding 'Anonymous Pro' font family
[Embed(source='/fonts/Anonymous Pro B.ttf', embedAsCFF='true', fontName='AnonymousPro', fontWeight='bold', fontStyle='normal', mimeType='application/x-font')]
private static var AnonymousProB:Class;
[Embed(source='/fonts/Anonymous Pro BI.ttf', embedAsCFF='true', fontName='AnonymousPro', fontWeight='bold', fontStyle='italic', mimeType='application/x-font')]
private static var AnonymousProBI:Class;
[Embed(source='/fonts/Anonymous Pro I.ttf', embedAsCFF='true', fontName='AnonymousPro', fontWeight='normal', fontStyle='italic', mimeType='application/x-font')]
private static var AnonymousProI:Class;
[Embed(source='/fonts/Anonymous Pro.ttf', embedAsCFF='true', fontName='AnonymousPro', fontWeight='normal', fontStyle='normal', mimeType='application/x-font')]
private static var AnonymousPro:Class;
// TextFlow options
textFlow.fontLookup = FontLookup.EMBEDDED_CFF;
textFlow.cffHinting = CFFHinting.HORIZONTAL_STEM;
textFlow.renderingMode = RenderingMode.CFF;